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Electrochemical Biosensors

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Electrochemical biosensor is a device that elucidates the electron transfer mechanism between the  biological recognition element and electrode surface by signalling the change in current at applied electrode potential. The measurable change in current obtained due to redox reaction is concentration dependent. The key component of electrochemical biosensor is the electrode, employed as a solid support for immobilisation biomolecules and electron transfer. The high performance of sensor is achieved by adapting new strategies of surface modification. This implies the synthesis of new materials based on the electrochemical properties of biorecognition element. Our group aims at developing ultrasensitive electrochemical biosensors for health care diagnostics with particular attention to paper based flexible electrodes. A panel of reports has already been published for a different biomolecules like Glucose, Dopamine and Cholesterol. Besides, recently our group started working on detection of capsaicin which is one of the hottest topics in the field of medicine and the food industry. Additionally, the area of research includes development of electrochemical immunosensor aimed at early detection of small cell lung cancer for point of care detection. 

Publications:

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  1. “Selective and sensitive determination of capsaicin using polymelamine formaldehyde decorated over carbon nanotubes”, D. Mehta, N. Thakur and T. C. Nagaiah,* Mater. Adv., 2022, 3, 5027-5033.

  2. “Fabrication of NiFeB flexible electrode via electroless deposition towards selective and sensitive detection of dopamine” A. Kafle, N. Thakur and T. C. Nagaiah,* J. Mater. Chem. B, 2022, 10, 3681.

  3. “A novel NiVP/Pi based flexible sensor for direct electrochemical ultrasensitive detection of cholesterol”, N. Thakur, D. Mandal* and T. C. Nagaiah,* Chem. Commun., 2022, 58, 2706–2709.

  4. “Ultrasensitive electrochemical biosensors for dopamine and cholesterol: Recent advances, challenges and strategies”, N. Thakur†, D. Gupta†, D. Mandal* and T. C. Nagaiah,* Chem. Commun., 2021, 57, 13084-13113.

  5. “Highly sensitive non-enzymatic electrochemical glucose sensor surpassing water oxidation interference”. N. Thakur, D. Mandal* and T. C. Nagaiah,* J. Mater. Chem. B, 2021, 9, 8399.

  6. “Ultrasensitive and highly selective detection of dopamine by a NiFeP based flexible electrochemical sensor”. N. Thakur, A. Chaturvedi, D. Mandal* and T. C. Nagaiah,* Chem. Commun., 2020, 56, 8448-8451.

  7. “PVIM–Co POM/MNC composite as a flexible electrode for the ultrasensitive and highly selective non-enzymatic electrochemical detection of cholesterol”, N. Thakur, M. Kumar, S. D. Adhikary, D. Mandal* and T. C. Nagaiah,* Chem. Commun., 2019, 55, 5021-5024.

  8. “Ultrasensitive and Highly Selective Electrochemical Detection of Dopamine Using Poly(ionic liquids)–Cobalt Polyoxometalate/CNT Composite”, N. Thakur, S. D. Adhikary, M. Kumar, D. Mehta, A. K. Padhan, D. Mandal,* and T. C. Nagaiah,* ACS omega, 2018, 3, 2966-2973.

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